每年出版 4 期
ISSN 打印: 0731-8898
ISSN 在线: 2162-6537
Indexed in
A Paradox of Cadmium: A Carcinogen That Impairs the Capability of Human Breast Cancer Cells To Induce Angiogenesis
摘要
Cadmium, a highly persistent heavy metal, has been categorized as a human carcinogen. Even though it is known that cadmium acts as estrogens in breast cancer cells, several studies failed to demonstrate whether cadmium is a causal factor for breast cancer. The lack of a strong association between cadmium and breast cancer could be found in the antiangiogenic properties of this heavy metal, which might counteract its carcinogenic properties in the progression of breast cancer. In this study, we exposed estrogen-responsive breast cancer cells to subtoxic levels of cadmium, and we evaluated their angiogenic potential using the chick embryo chorioallantoic membrane assay. Exposure of breast cancer cells to subtoxic levels of cadmium significantly inhibited the angiogenic potential of the breast cancer cell line, suggesting the possibility that cadmium might negatively regulate the production of proangiogenic factors in breast cancer cells. Our results suggest that cadmium might exert a paradoxical effect in breast cancer: on the one hand, it could promote carcinogenesis, and, on the other hand, it could delay the onset of tumors by inhibiting breast cancer cell-induced angiogenesis.
-
Kurowska Ewa, Bal Wojciech, , 4, 2010. Crossref
-
Pacini Stefania, Fiore Maria G., Magherini Stefano, Morucci Gabriele, Branca Jacopo J.V., Gulisano Massimo, Ruggiero Marco, Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Medical Hypotheses, 79, 3, 2012. Crossref
-
Zhang Zhen, Bi Caifeng, Buac Daniela, Fan Yuhua, Zhang Xia, Zuo Jian, Zhang Pengfei, Zhang Nan, Dong Lili, Dou Q. Ping, Organic cadmium complexes as proteasome inhibitors and apoptosis inducers in human breast cancer cells, Journal of Inorganic Biochemistry, 123, 2013. Crossref
-
Pacini Stefania, Morucci Gabriele, Punzi Tiziana, Gulisano Massimo, Ruggiero Marco, Gc protein-derived macrophage-activating factor (GcMAF) stimulates cAMP formation in human mononuclear cells and inhibits angiogenesis in chick embryo chorionallantoic membrane assay, Cancer Immunology, Immunotherapy, 60, 4, 2011. Crossref
-
Jing Yi, Liu Ling-Zhi, Jiang Yue, Zhu Yingxue, Guo Nancy Lan, Barnett John, Rojanasakul Yon, Agani Faton, Jiang Bing-Hua, Cadmium Increases HIF-1 and VEGF Expression through ROS, ERK, and AKT Signaling Pathways and Induces Malignant Transformation of Human Bronchial Epithelial Cells, Toxicological Sciences, 125, 1, 2012. Crossref
-
Zepeda Ramiro, Castillo Paula, Sáez Daniel, Llanos Miguel N., Ronco Ana M., Cardiac Tissue Injury Resistance During Myocardial Infarction at Adulthood by Developmental Exposure to Cadmium, Cardiovascular Toxicology, 12, 1, 2012. Crossref
-
Mulware Stephen Juma, The Mammary Gland Carcinogens: The Role of Metal Compounds and Organic Solvents, International Journal of Breast Cancer, 2013, 2013. Crossref
-
Liu Fuhong, Wang Bei, Li Liqun, Dong Fengyun, Chen Xiaocui, Li Yan, Dong Xiuzhen, Wada Youichiro, Kapron Carolyn, Liu Ju, Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells, International Journal of Environmental Research and Public Health, 12, 9, 2015. Crossref
-
Lappano Rosamaria, Malaguarnera Roberta, Belfiore Antonino, Maggiolini Marcello, Recent advances on the stimulatory effects of metals in breast cancer, Molecular and Cellular Endocrinology, 457, 2017. Crossref
-
Florea Ana-Maria, Büsselberg Dietrich, Metals and Breast Cancer: Risk Factors or Healing Agents?, Journal of Toxicology, 2011, 2011. Crossref
-
Jablonska E., Socha K., Reszka E., Wieczorek E., Skokowski J., Kalinowski L., Fendler W., Seroczynska B., Wozniak M., Borawska M.H., Wasowicz W., Cadmium, arsenic, selenium and iron– Implications for tumor progression in breast cancer, Environmental Toxicology and Pharmacology, 53, 2017. Crossref
-
Zhang Nan, Fan Yuhua, Huang Guimei, Buac Daniela, Bi Caifeng, Ma Yanfei, Wang Xinping, Zhang Zhen, Zhang Xia, Dou Q. Ping, l-Tryptophan Schiff base cadmium(II) complexes as a new class of proteasome inhibitors and apoptosis inducers in human breast cancer cells, Inorganica Chimica Acta, 466, 2017. Crossref
-
Hong X, Zhang L, Sun Q, Environmental Pollutants on Angiogenesis and Vascular Development, in Comprehensive Toxicology, 2018. Crossref
-
Branca JacopoJunio Valerio, Morucci Gabriele, Pacini Alessandra, Cadmium-induced neurotoxicity: still much ado, Neural Regeneration Research, 13, 11, 2018. Crossref
-
Amadou Amina, Praud Delphine, Coudon Thomas, Danjou Aurélie M.N., Faure Elodie, Leffondré Karen, Le Romancer Muriel, Severi Gianluca, Salizzoni Pietro, Mancini Francesca Romana, Fervers Béatrice, Chronic long‐term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort, International Journal of Cancer, 146, 2, 2020. Crossref
-
Wei Tianshu, Jia Jin, Wada Youichiro, Kapron Carolyn M., Liu Ju, Dose dependent effects of cadmium on tumor angiogenesis, Oncotarget, 8, 27, 2017. Crossref
-
Gheorghiu Mihaela, Stănică Luciana, Ghinia Tegla Miruna G., Polonschii Cristina, Bratu Dumitru, Popescu Octavian, Badea Tudor, Gheorghiu Eugen, Cellular sensing platform with enhanced sensitivity based on optogenetic modulation of cell homeostasis, Biosensors and Bioelectronics, 154, 2020. Crossref
-
Fadaei Homeyra, Mirhosseiniardakani Soheilaalsadat, Farajzadeh Asghar, Aghayan Seyed Sharokh, Jafarisani Moslem, Garmabi Behzad, Aqueous‐alcoholic Ferulla extract reduces memory impairments in rats exposed to cadmium chloride , Brain and Behavior, 11, 8, 2021. Crossref
-
Baj Jacek, Teresiński Grzegorz, Kowalska Beata, Krajka Tomasz, Buszewicz Grzegorz, Forma Alicja, Flieger Wojciech, Karakuła Kaja Hanna, Kędzierawski Paweł, Cywka Tomasz, Flieger Jolanta, ICP-MS Multi-Elemental Analysis of the Human Meninges Collected from Sudden Death Victims in South-Eastern Poland, Molecules, 27, 6, 2022. Crossref
-
Mansouri Borhan, Ramezani Zana, Yousefinejad Vahid, Nakhaee Samaneh, Azadi Namamali, Khaledi Peyman, Nikkhoo Bahram, Hassanzadeh Kambiz, Rahimi Azin, Association between trace elements in cancerous and non-cancerous tissues with the risk of breast cancers in western Iran, Environmental Science and Pollution Research, 29, 8, 2022. Crossref