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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Matrix Metalloproteinase-9 as a Potential Tumor Marker in Breast Cancer

卷 32, 册 2, 2013, pp. 115-129
DOI: 10.1615/JEnvironPatholToxicolOncol.2013008166
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摘要

This study aimed to detect the comparative expression and activity of matrix metalloproteinase-9 (MMP-9) and its correlation with known pathological parameters such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) in 81 malignant breast tumors and adjacent normal breast tissues and in blood sera of these patients from different clinical TNM stages (ductal carcinoma in situ to T4) of breast cancer. MMP-9 was highly expressed in node-positive tumors and the preoperative blood serum of patients, but MMP-9 activity was appreciably inhibited in blood serum samples collected after surgery. The mature form of MMP-9 (84 kD) was expressed only in clinical stage III tumors (T2−4). Appreciable reduction of tissue inhibitor of metalloproteinase 1, phosphorylation of epidermal growth factor receptor, and translocation of nuclear factor-κΒ suggested their possible role in MMP-9 activation in HER2-positive breast cancer Overexpression and activation of MMP-9 predicted a higher stage of hormone-sensitive ductal breast carcinoma. Downregulation of the endogenous inhibitor of MMP-9, tissue inhibitor of metalloproteinase 1, and translocation of the transcription factor nuclear factor-κΒ in tumors may have an appreciable role in the overexpression of MMP-9. However, MMP-9 activation was not correlated with expression of estrogen and progesterone receptors. Evaluation of MMP-9 expression may provide valuable information about breast cancer treatment.

对本文的引用
  1. Kim Mi-Sung, Lim Do Young, Kim Jong-Eun, Chen Hanyong, Lubet Ronald A., Dong Zigang, Bode Ann M., Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells, Molecular Carcinogenesis, 54, 12, 2015. Crossref

  2. Tang Dabei, Piao Ying, Zhao Shu, Mu Xudong, Li Shuo, Ma Wenjie, Song Ying, Wang Jingxuan, Zhao Wenhui, Zhang Qingyuan, Expression and correlation of matrix metalloproteinase-9 and heparanase in patients with breast cancer, Medical Oncology, 31, 7, 2014. Crossref

  3. Liang Jingyao, Zhao Tian, Yang Juan, Li Wei, Zhang Fang, Zhang Sanquan, Huang Zhenming, Lin Rihua, Zhang Xibao, MMP-9 gene polymorphisms (rs3918242, rs3918254 and rs4810482) and the risk of psoriasis vulgaris: No evidence for associations in a Chinese Han population, Immunology Letters, 168, 2, 2015. Crossref

  4. Liu Ying, Nguyen Nhi, Colditz Graham A, Links between Alcohol Consumption and Breast Cancer: A Look at the Evidence, Women's Health, 11, 1, 2015. Crossref

  5. Pal Sekhar, Ganguly Kirat Kumar, Mandal Shyamsundar, Biswas Jaydip, Chatterjee Amitava, Tumor Cell-Extracellular Matrix Interaction Modulates MMP-1 in Breast Cancer, Journal of Cancer Therapy, 06, 04, 2015. Crossref

  6. Regier Mary C., Maccoux Lindsey J., Weinberger Emma M., Regehr Keil J., Berry Scott M., Beebe David J., Alarid Elaine T., Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments, Biomedical Microdevices, 18, 4, 2016. Crossref

  7. Matrix Metalloproteinases in the Interstitial Space, in Proteolysis in the Interstitial Space, 2016. Crossref

  8. Chowdhury Animesh, Romaniello Donatella, Ghosh Soma, Chakraborti Tapati, Roy Soumitra, Chakraborti Sajal, Protease, an Advance Therapeutic Target in Cancer, in Pathophysiological Aspects of Proteases, 2017. Crossref

  9. Wang Shaojun, Zhang Xiaofei, Wang Guimei, Cao Bin, Yang Hong, Jin Lipeng, Cui Mingjuan, Mao Yongjun, Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells, BMC Cancer, 19, 1, 2019. Crossref

  10. del Pilar Chantada-Vázquez María, López Antonio Castro, Vence María García, Vázquez-Estévez Sergio, Acea-Nebril Benigno, Calatayud David G., Jardiel Teresa, Bravo Susana B., Núñez Cristina, Proteomic investigation on bio-corona of Au, Ag and Fe nanoparticles for the discovery of triple negative breast cancer serum protein biomarkers, Journal of Proteomics, 212, 2020. Crossref

  11. Smart Emily, Semina Svetlana E, Frasor Jonna, Update on the Role of NFκB in Promoting Aggressive Phenotypes of Estrogen Receptor–Positive Breast Cancer, Endocrinology, 161, 10, 2020. Crossref

  12. García-Sampedro Andrés, Acedo Pilar, Pereira Stephen P., Established and Emerging Biomarkers for Prediction, Early Detection, and Prognostication of Cholangiocarcinoma, in Diagnosis and Management of Cholangiocarcinoma, 2021. Crossref

  13. Schunkert Elisa M., Zhao Wanzhou , Zänker Kurt, Breast Cancer Recurrence Risk Assessment: Is Non-Invasive Monitoring an Option?, Biomedicine Hub, 3, 3, 2018. Crossref

  14. Lee JaeWoong, Yun Jun Yeon, Lee Won Cheol, Choi Seongwook, Lim JaeHeung, Jeong Hyeri, Shin Dong-Sik, Park Young June, A reference electrode-free electrochemical biosensor for detecting MMP-9 using a concentric electrode device, Sensors and Actuators B: Chemical, 240, 2017. Crossref

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