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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Nephroprotective Effect of Jaggery against Acute and Subchronic Toxicity of Acetaminophen in Wistar Rats

卷 31, 册 3, 2012, pp. 265-272
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i3.70
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摘要

The present investigation was planned to evaluate the nephroprotective activity of jaggery against acetaminophen (APAP)-induced renal damage in rats. The protective activity of jaggery at different doses (250, 500, and 750 mg/kg, orally) was evaluated against oxidative damage induced by APAP administration (2 g/kg, once orally in acute exposure; 20 mg/kg, orally for 21 days in subchronic exposure) in rats. APAP administration significantly increased the levels of serum urea, creatinine, and renal lipid peroxidation (LPO), whereas substantial decreases were observed in levels of glutathione (GSH), adenosine triphosphatase (ATPase), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx) enzymatic activities after APAP administration. Administration of jaggery significantly moved the studied parameters toward normal levels and also reversed the histopathologic alterations. Thus, jaggery can be used to reduce renal damage and may serve as an alternative medicine in the treatment of renal etiologies.

对本文的引用
  1. Mansour Sherif W., Sangi Sibghatullah, Harsha Sree, Khaleel Mueen A., Ibrahim A.R.N., Sensibility of male rats fertility against olive oil, Nigella sativa oil and pomegranate extract, Asian Pacific Journal of Tropical Biomedicine, 3, 7, 2013. Crossref

  2. Tamai Satoshi, Iguchi Takuma, Niino Noriyo, Mikamoto Kei, Sakurai Ken, Sayama Ayako, Shimoda Hitomi, Takasaki Wataru, Mori Kazuhiko, A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human, The Journal of Toxicological Sciences, 42, 1, 2017. Crossref

  3. Sohail Nida, Hira Khan, Tariq Amna, Sultana Viqar, Ehteshamul-Haque Syed, Marine macro-algae attenuates nephrotoxicity and hepatotoxicity induced by cisplatin and acetaminophen in rats, Environmental Science and Pollution Research, 26, 24, 2019. Crossref

  4. Ebadi Samarghand, Azlan Azrina, Nutritional Composition and Role of Non-centrifugal Sugar (NCS) in Human Health, Current Nutrition & Food Science, 17, 3, 2021. Crossref

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