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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Daidzein Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice by Regulating NF-κB Signaling

卷 38, 册 1, 2019, pp. 29-39
DOI: 10.1615/JEnvironPatholToxicolOncol.2018027531
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摘要

Ulcerative colitis (UC) and Crohn’s disease (CD) are collectively referred to as inflammatory bowel diseases (IBDs). The increased pathogenesis of UC leads to a series of complications. We aimed to analyze the anticolitic effect of daidzein (DA) in a dextran sulfate sodium (DSS)-induced colitis mouse model and in activated macrophage RAW264.7 cells. Thirty BALB/c male mice were randomly divided into three groups: control, DSS-treated, and DSS DA (10 mg/kg body weight for seven days). DA supplementation was found to improve the disease activity index, colon length, and spleen weight. Microscopic analysis revealed that DSS-induced mice showed more inflammatory cell infiltration and erosion in the villi. Supplementation of DA reduced these signs significantly. Furthermore, oral administration of DA decreased the level of myeloperoxidase (MPO) and inhibited the expression of p65-NF-κB, p-IκB-α, and p-IKK as well as several inflammatory factors, including TNF-α, IL-1β, and IL-6, in the colonic tissues. DA also inhibited the production of nitric oxide and prostaglandin E2 in LPS-stimulated RAW 264.7 macrophages. Taken together, these results suggest that DA could inhibit DSS-induced ulcerative colitis and decrease inflammatory factor expression. Thus, DA might be applicable in the treatment of UC.

对本文的引用
  1. Peng Lu-Yuan, Yuan Meng, Song Ke, Yu Jia-Lin, Li Jing-He, Huang Jiang-Ni, Yi Peng-Fei, Fu Ben-Dong, Shen Hai-Qing, Baicalin alleviated APEC-induced acute lung injury in chicken by inhibiting NF-κB pathway activation, International Immunopharmacology, 72, 2019. Crossref

  2. Yang Jie, Li Kailing, He Dan, Gu Jing, Xu Jingyu, Xie Jiaxi, Zhang Min, Liu Yuying, Tan Qunyou, Zhang Jingqing, Toward a better understanding of metabolic and pharmacokinetic characteristics of low-solubility, low-permeability natural medicines, Drug Metabolism Reviews, 52, 1, 2020. Crossref

  3. Al-Nakkash Layla, Kubinski Aaron, Soy Isoflavones and Gastrointestinal Health, Current Nutrition Reports, 9, 3, 2020. Crossref

  4. Wu Ze-Yu, Sang Li-Xuan, Chang Bing, Isoflavones and inflammatory bowel disease, World Journal of Clinical Cases, 8, 11, 2020. Crossref

  5. Yu Guijuan, Liu Yang, Ou Weihao, Dai Jihong, Ai Qinghui, Zhang Wenbing, Mai Kangsen, Zhang Yanjiao, The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets, Scientific Reports, 11, 1, 2021. Crossref

  6. Mahoro Patience, Moon Hye-Jung, Yang Hee-Jong, Kim Kyung-Ah, Cha Youn-Soo, Protective Effect of Gochujang on Inflammation in a DSS-Induced Colitis Rat Model, Foods, 10, 5, 2021. Crossref

  7. Wang Yue, Nan Xuemei, Zhao Yiguang, Jiang Linshu, Wang Hui, Hua Dengke, Zhang Fan, Wang Yapin, Liu Jun, Yao Junhu, Xiong Benhai, Dietary supplementation with inulin improves lactation performance and serum lipids by regulating the rumen microbiome and metabolome in dairy cows, Animal Nutrition, 7, 4, 2021. Crossref

  8. Wang Xuerui, Yin Zequn, Meng Xianshe, Yang Daigang, Meng Huawen, Liao Chenzhong, Wei Lingling, Chen Yuanli, Yang Xiaoxiao, Han Jihong, Duan Yajun, Zhang Shuang, Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice, Journal of Functional Foods, 92, 2022. Crossref

  9. Yang Hee-Jong, Jeong Su-Ji, Ryu Myeong Seon, Ha Gwangsu, Jeong Do-Youn, Park Young Mi, Lee Hak Yong, Bae Jun Sang, Protective effect of traditional Korean fermented soybean foods (doenjang) on a dextran sulfate sodium-induced colitis mouse model, Food & Function, 13, 16, 2022. Crossref

  10. Koyama Yoshihisa, Kobayashi Yuki, Hirota Ikuei, Sun Yuanjie, Ohtsu Iwao, Imai Hiroe, Yoshioka Yoshichika, Yanagawa Hiroto, Sumi Takuya, Kobayashi Hikaru, Shimada Shoichi, A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent, Scientific Reports, 12, 1, 2022. Crossref

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