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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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A Simple One-Step Protocol for Preparing Small-Sized Doxorubicin-Loaded Liposomes

卷 27, 册 3, 2008, pp. 181-189
DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i3.20
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摘要

A simple, single-step, extrusion-free protocol for preparing doxorubicin-loaded liposomes (100—150 nm), based on the ethanol injection method (EIM), is described. Efficient encapsulation of doxorubicin (up to 98%) was obtained concomitantly with liposome preparation avoiding the need for an additional loading step. Parameters such as stock concentration of phospholipid, injection ratio, lipid composition, and drug-to-phospholipid ratio affected the resultant liposome size and magnitude of doxorubicin encapsulation. A lipid stock concentration (50 mM) and injection ratio (1:10) resulted in 96.0 ± 2.92% encapsulation efficiency of doxorubicin (drug-to-lipid mole ratio: 0.192) and mean diameter of 135 ± 2.32 nm for SCOL-2 formulation (DSPC/ cholesterol /oleic acid: 2/2/1; molar ratios). Replacement of phospholipid DSPC with DMPC or DPPC did not affect the mean liposome size and doxorubicin-encapsulation efficiency. These findings offer promise for scale-up and development on a large-scale production of doxorubicin-loaded liposomes for effective cancer therapy.

对本文的引用
  1. Jaafar-Maalej Chiraz, Diab Roudayna, Andrieu Véronique, Elaissari Abdelhamid, Fessi Hatem, Ethanol injection method for hydrophilic and lipophilic drug-loaded liposome preparation, Journal of Liposome Research, 20, 3, 2010. Crossref

  2. Roberts Steven A., Parikh Neil, Blower Ryan J., Agrawal Nitin, SPIN: rapid synthesis, purification, and concentration of small drug-loaded liposomes, Journal of Liposome Research, 28, 4, 2018. Crossref

  3. Hashemi Seyed Hesamoddin, Montazer Majid, Naghdi Nasser, Toliyat Tayebeh, Formulation and characterization of alprazolam-loaded nanoliposomes: screening of process variables and optimizing characteristics using RSM, Drug Development and Industrial Pharmacy, 44, 2, 2018. Crossref

  4. Wang Jiemin, Wu Junyong, Li Yongjiang, Wen Jing, Cai Jiaxin, Tang Tiantian, Hu Xiongbin, Xiang Daxiong, The Brief Analysis of Peptide-combined Nanoparticle: Nanomedicine’s Unique Value, Current Protein & Peptide Science, 21, 4, 2020. Crossref

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