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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Modulation of c-Kit/SCF Pathway Leads to Alterations in Topoisomerase-I Activity in Small Cell Lung Cancer

卷 23, 册 4, 2004, 16 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i4.10
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摘要

Small cell lung cancer (SCLC) is an aggressive type of lung cancer, for which cytotoxic chemotherapy appears to have reached its maximal efficacy. This neoplasm is characterized by the overexpression of several receptor tyrosine kinases (RTKs), especially c-Kit. The ligand for c-Kit is stem cell factor (SCF). In SCLC, SCF can influence c-Kit activation by autocrine or paracrine mechanisms. We have recently shown that the c-Kit/SCF pathway is operational in SCLC and can be inhibited by Glivec (STI571). Because the inhibition of topoisomerase-I (topo-I) is one approach used to treat SCLC, we determined the effects of c-Kit/SCF signaling on topo-I activity. A unique phosphorylation of c-Kit on amino acid 823 and amino acid 703 was identified with the SCF stimulation of H526 cells. We demonstrate that with SCF stimulation over 16 hours (dose response 0−100 ng/mL) in H526 SCLC cells (c-Kit positive, SCF responsive), a decrease in topo-I activity was observed, whereas in H82 SCLC cells (c-Kit negative, SCF unresponsive) there was no modulation of topo-I activity by SCF. Using STI571 (5 μM, 16 hours) to inhibit the c-Kit pathway following stimulation with SCF (100 ng/mL), an upregulation of topo-I activity was observed in H526 cells but not in H82 cells. Performing viability assays, we show that STI571 in combination with topo-I inhibition by camptothecin or SN38, the active metabolite of irinotecan, can cooperatively inhibit H526 cell viability (but not H82 cell viability) for 72 hours. We also show that STI571 does not directly inhibit topo-I activity in SCLC. The combination of STI571 with topo-I inhibition could provide a useful combination in the treatment of SCLC.

对本文的引用
  1. DiNitto J. P., Deshmukh G. D., Zhang Y., Jacques S. L., Coli R., Worrall J. W., Diehl W., English J. M., Wu J. C., Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance, Journal of Biochemistry, 147, 4, 2010. Crossref

  2. Johnson Faye M., Krug Lee M., Tran Hai T., Shoaf Stephanie, Prieto Victor G., Tamboli Pheroze, Peeples Beverly, Patel Jyoti, Glisson Bonnie S., Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma, Cancer, 106, 2, 2006. Crossref

  3. Locascio Lauren E., Donoghue Daniel J., KIDs rule: regulatory phosphorylation of RTKs, Trends in Biochemical Sciences, 38, 2, 2013. Crossref

  4. Ferguson Benjamin D., Liu Ren, Rolle Cleo E., Tan Yi-Hung Carol, Krasnoperov Valery, Kanteti Rajani, Tretiakova Maria S., Cervantes Gustavo M., Hasina Rifat, Hseu Robyn D., Iafrate A. John, Karrison Theodore, Ferguson Mark K., Husain Aliya N., Faoro Leonardo, Vokes Everett E., Gill Parkash S., Salgia Ravi, Miller Todd W., The EphB4 Receptor Tyrosine Kinase Promotes Lung Cancer Growth: A Potential Novel Therapeutic Target, PLoS ONE, 8, 7, 2013. Crossref

  5. Hu Anling, Huang Juan, Li Shiyue, Gao Yang, Wu Li, Deng Jiang, Liu Jie, Gong Qihai, Li Lisheng, Xu Shangfu, Involvement of stromal cell-derived factor-1α (SDF-1α), stem cell factor (SCF), fractalkine (FKN) and VEGF in TSG protection against intimal hyperplasia in rat balloon injury, Biomedicine & Pharmacotherapy, 110, 2019. Crossref

  6. Cagle Philip T., Jagirdar Jaishree, Popper Helmut H., Molecular Genetics of Lung and Pleural Neoplasms, in Dail and Hammar’s Pulmonary Pathology, 2008. Crossref

  7. Allen Timothy Craig, Sienko Anna, Cagle Philip T., Response to Conventional Therapy and Targeted Molecular Therapy, in Molecular Pathology of Lung Diseases, 1, 2008. Crossref

  8. Pham Duc Daniel M., Guhan Samantha, Tsao Hensin, KIT and Melanoma: Biological Insights and Clinical Implications, Yonsei Medical Journal, 61, 7, 2020. Crossref

  9. Levy A., Malouf G.G., Besse B., Massard C., Soria J.-C., Thérapies moléculaires ciblées dans le cancer du poumon à petites cellules, Bulletin du Cancer, 97, 5, 2010. Crossref

  10. Foster Brittni M., Langsten Kendall L., Mansour Ammar, Shi Lihong, Kerr Bethany A., Tissue distribution of stem cell factor in adults, Experimental and Molecular Pathology, 122, 2021. Crossref

  11. Shraim Ala’a S., Hunaiti Abdelrahim, Awidi Abdalla, Alshaer Walhan, Ababneh Nidaa A., Abu-Irmaileh Bashaer, Odeh Fadwa, Ismail Said, Developing and Characterization of Chemically Modified RNA Aptamers for Targeting Wild Type and Mutated c-KIT Receptor Tyrosine Kinases, Journal of Medicinal Chemistry, 63, 5, 2020. Crossref

  12. Huguet Florence, Giocanti Nicole, Hennequin Christophe, Croisy Martine, Touboul Emmanuel, Favaudon Vincent, Growth inhibition by STI571 in combination with radiation in human chronic myelogenous leukemia K562 cells, Molecular Cancer Therapeutics, 7, 2, 2008. Crossref

  13. Chen Tingchao, Burke Kathleen A., Zhan Yuxia, Wang Xingchao, Shibata Darryl, Zhao Yi, IL-12 Facilitates Both the Recovery of Endogenous Hematopoiesis and the Engraftment of Stem Cells after Ionizing Radiation, Experimental Hematology, 35, 2, 2007. Crossref

  14. Rager Taylor, Eckburg Adam, Patel Meet, Qiu Rong, Gantiwala Shahina, Dovalovsky Katrina, Fan Kelly, Lam Katie, Roesler Claire, Rastogi Aayush, Gautam Shruti, Dube Namrata, Morgan Bridget, Nasifuzzaman S M, Ramaswami Dhruv, Gnanasekar Varun, Smith Jeffrey, Merchant Aftab, Puri Neelu, Treatment of Metastatic Melanoma with a Combination of Immunotherapies and Molecularly Targeted Therapies, Cancers, 14, 15, 2022. Crossref

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