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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Correlation of Apoptosis with Comet Formation Induced by Tea Polyphenols in Human Leukemia Cells

卷 24, 册 2, 2005, pp. 115-128
DOI: 10.1615/JEnvPathToxOncol.v24.i2.50
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摘要

Induction of apoptosis is an important approach to cancer control. Apart from morphological changes in cells, apoptosis is characterized by fragmentation of nuclear DNA. The characteristic DNA ladder formation that is observed on gel electrophoresis does not reflect the DNA breakdown in individual cells; contributions from small subpopulations are usually overlooked. On the other hand, alkaline comet assay as measured by single cell gel electrophoresis accurately measures DNA fragmentation at a single cell level. The comet assay was originally developed as a cytogenetic test to measure the genotoxicity of various chemicals. However, the comet image generated by an apoptotic cell is different from that obtained with a cell treated for a short time with a genotoxic agent. In the present study using human leukemic cells, typical apoptotic features such as morphological characteristics, FACS analysis, caspase activation, and expression of apoptosis-related genes as induced by tea polyphenols have been found to correlate with the comet tail formation. It is apparent from the high degree of correlation observed between the comet tail moment and each parameter of apoptosis that the comet assay can accurately reflect the measure of DNA fragmentation and, hence, can be used to detect a cell undergoing apoptosis.

对本文的引用
  1. Knasmüller Siegfried, Nersesyan Armen, Mišík Miroslav, Gerner Christopher, Mikulits Wolfgang, Ehrlich Veronika, Hoelzl Christine, Szakmary Akos, Wagner Karl-Heinz, Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview, British Journal of Nutrition, 99, E-S1, 2008. Crossref

  2. Saadat Farshid, Khorramizadeh Mohammad Reza, Mirshafiey Abbas, Chemoprevention by Pyrimethamine, Immunopharmacology and Immunotoxicology, 27, 2, 2005. Crossref

  3. Elkady Ayman I, Hussein Rania A, El-Assouli Sufian M, Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-κB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes, Asian Pacific Journal of Cancer Prevention, 17, 4, 2016. Crossref

  4. Yang Ming-Ling, The effects of cytotoxicity and genotoxicity induced by 2,2-bis[4-(acryloxypropoxy)phenyl]propane via caspases in human gingival fibroblasts, Toxicology and Industrial Health, 30, 8, 2014. Crossref

  5. Roy Madhumita, Datta Amitava, Molecular Mechanisms of Phytochemical Actions in Cancer, in Cancer Genetics and Therapeutics, 2019. Crossref

  6. Savi Luciane A., Barardi Célia R. M., Simões Cláudia M. O., Evaluation of Antiherpetic Activity and Genotoxic Effects of Tea Catechin Derivatives, Journal of Agricultural and Food Chemistry, 54, 7, 2006. Crossref

  7. Zhao Yonghuan, Chang Sam K. C., Qu Gang, Li Tianwen, Cui Hongbin, β-Sitosterol Inhibits Cell Growth and Induces Apoptosis in SGC-7901 Human Stomach Cancer Cells, Journal of Agricultural and Food Chemistry, 57, 12, 2009. Crossref

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