每年出版 4 期
ISSN 打印: 0731-8898
ISSN 在线: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Gracilaria bursa-pastoris (Gmelin) Silva Extract Attenuates Ultraviolet B Radiation−Induced Oxidative Stress in Human Keratinocytes
Get access
摘要
The purpose of this study was to assess the protective effects of an ethanol extract derived from the red alga Gracilaria bursa-pastoris (Gmelin) Silva (GBE) on ultraviolet B (UVB)−irradiated human HaCaT keratinocytes. GBE exhibited scavenging activity against intracellular reactive oxygen species that were induced by either hydrogen peroxide or UVB radiation. In addition, both the superoxide anion and the hydroxyl radical were scavenged by GBE in cell-free systems. GBE absorbed light in the UVB range (280−320 nm) of the electromagnetic spectrum and lessened the extent of UVB-induced oxidative damage to cellular lipids, proteins, and DNA. Finally, GBE-treated keratinocytes showed a reduction in UVB-induced apoptosis, as exemplified by fewer apoptotic bodies. These results suggest that GBE exerts cytoprotective actions against UVB-stimulated oxidative stress by scavenging ROS and absorbing UVB rays, thereby attenuating injury to cellular constituents and preventing cell death.
-
Maurya Pawan Kumar, Noto Cristiano, Rizzo Lucas B., Rios Adiel C., Nunes Sandra O.V., Barbosa Décio Sabbatini, Sethi Sumit, Zeni Maiara, Mansur Rodrigo B., Maes Michael, Brietzke Elisa, The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65, 2016. Crossref
-
Torres Priscila, Santos Janaína Pires, Chow Fungyi, dos Santos Déborah Y.A.C., A comprehensive review of traditional uses, bioactivity potential, and chemical diversity of the genus Gracilaria (Gracilariales, Rhodophyta), Algal Research, 37, 2019. Crossref