图书馆订阅: Guest
环境病理学,毒理学和肿瘤学期刊

每年出版 4 

ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Expression of MMP1 in Surgical and Radiation-Impaired Wound Healing and Its Effects on the Healing Process

卷 21, 册 1, 2002, 8 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i1.70
Get accessGet access

摘要

Radiation-impaired wound is characterized by delayed healing, nonhealing, and carcinogenesis. The mechanism remains unclear. Matrix metalloproteinases (MMPs) are one family of key regulators of the process of wound healing. Their abnormal expression plays important roles in the formation of some chronic skin ulcers. The objective of this project was to study the expression of MMP1 in surgical and radiation-impaired wound healing and its effects on the healing process and tissue remodeling. A rat model of radiation-impaired wound healing was used. Routine light microscopy, electron microscopy, immunohistochemistry, and in situ hybridization, all of which enabled the detection of MMPI expression during the healing process, were performed. The wound healing process was impaired and delayed. In rats receiving 25Gy g-ray locally, the irradiated wounds healed 6 days later than the nonirradiated controls. The following changes in MMP1 expression were found: (1) In the early inflammatory phase and in the period of granulation tissue formation, MMP1 expression was only slightly if at all affected in the newly formed epidermis of irradiated wounds compared with controls. Later, the epidermal expression of MMP1 in radiation wounds was comparatively increased following the delay of the healing process. (2) MMP1 expression in irradiated wounds was markedly decreased in fibroblasts, endothelial cells, and macrophages compared with controls. The expression phase was prolonged because of the delay of the healing process. The reduced expression of MMP1 in granulation tissue retards such important processes as cell migration, angiogenesis, and tissue remodeling, thus slowing the healing process. The expression ofMMPI in the proliferating keratinocytes may help re-epithelialization. However, in the late healing period, overexpression ofMMPI in the epidermis may hinder the establishment ofbasal membrane and the formation of granulation tissue, and affect the tissue remodeling process.

对本文的引用
  1. Lam Paula Y. P., Ho Ivy A. W., Tumor Tropism of Mesenchymal Stem Cells, in Stem Cell Therapeutics for Cancer, 2013. Crossref

  2. Zhao Ge, Hochwalt Phillip C., Usui Marcia L., Underwood Robert A., Singh Pradeep K., James Garth A., Stewart Philip S., Fleckman Philip, Olerud John E., Delayed wound healing in diabetic (db/db) mice with Pseudomonas aeruginosa biofilm challenge: a model for the study of chronic wounds, Wound Repair and Regeneration, 18, 5, 2010. Crossref

  3. Dorsett-Martin Wanda A., Rat models of skin wound healing: A review, Wound Repair and Regeneration, 12, 6, 2004. Crossref

  4. Zhao Ge, Usui Marcia L., Underwood Robert A., Singh Pradeep K., James Garth A., Stewart Philip S., Fleckman Philip, Olerud John E., Time course study of delayed wound healing in a biofilm-challenged diabetic mouse model, Wound Repair and Regeneration, 20, 3, 2012. Crossref

  5. Myckatyn Terence M., Cavallo Jaime A., Sharma Ketan, Gangopadhyay Noopur, Dudas Jason R., Roma Andres A., Baalman Sara, Tenenbaum Marissa M., Matthews Brent D., Deeken Corey R., The Impact of Chemotherapy and Radiation Therapy on the Remodeling of Acellular Dermal Matrices in Staged, Prosthetic Breast Reconstruction, Plastic and Reconstructive Surgery, 135, 1, 2015. Crossref

  6. Anumolu SivaNaga S., DeSantis Andrea S., Menjoge Anupa R., Hahn Rita A., Beloni John A., Gordon Marion K., Sinko Patrick J., Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds, Biomaterials, 31, 5, 2010. Crossref

  7. Middelkoop E., van den Bogaerdt A.J., Lamme E.N., Hoekstra M.J., Brandsma K., Ulrich M.M.W., Porcine wound models for skin substitution and burn treatment, Biomaterials, 25, 9, 2004. Crossref

  8. Gapski Ricardo, Hasturk Hatice, Van Dyke Thomas E., Oringer Richard J., Wang Shufang, Braun Thomas M., Giannobile William V., Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial, Journal of Clinical Periodontology, 36, 2, 2009. Crossref

  9. Shin Yong Cheol, Shin Dong-Myeong, Lee Eun Ji, Lee Jong Ho, Kim Ji Eun, Song Sung Hwa, Hwang Dae-Youn, Lee Jun Jae, Kim Bongju, Lim Dohyung, Hyon Suong-Hyu, Lim Young-Jun, Han Dong-Wook, Hyaluronic Acid/PLGA Core/Shell Fiber Matrices Loaded with EGCG Beneficial to Diabetic Wound Healing, Advanced Healthcare Materials, 5, 23, 2016. Crossref

  10. Berry James A. D., Miulli Dan E., Lam Benjamin, Elia Christopher, Minasian Julia, Podkovik Stacey, Wacker Margaret R. S., The neurosurgical wound and factors that can affect cosmetic, functional, and neurological outcomes, International Wound Journal, 16, 1, 2019. Crossref

  11. Haubner Frank, Ohmann Elisabeth, Pohl Fabian, Strutz Jürgen, Gassner Holger G, Wound healing after radiation therapy: Review of the literature, Radiation Oncology, 7, 1, 2012. Crossref

  12. Barr Tasha, Girke Thomas, Sureshchandra Suhas, Nguyen Christina, Grant Kathleen, Messaoudi Ilhem, Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating Leukocytes, The Journal of Immunology, 196, 1, 2016. Crossref

  13. Petreus Tudor, Antoniac Iulian, Sirbu Paul, Cotrutz Carmen Elena, Molecular Scissors: From Biomaterials Implant to Tissue Remodeling, in Biologically Responsive Biomaterials for Tissue Engineering, 1, 2013. Crossref

  14. Diaz Candice, Hayward Cindy J., Safoine Meryem, Paquette Caroline, Langevin Josée, Galarneau Josée, Théberge Valérie, Ruel Jean, Archambault Louis, Fradette Julie, Ionizing Radiation Mediates Dose Dependent Effects Affecting the Healing Kinetics of Wounds Created on Acute and Late Irradiated Skin, Surgeries, 2, 1, 2021. Crossref

  15. Jafari M., Schneider-Bordat L., Hersant B., Biological mesh used to repair perineal hernias following abdominoperineal resection for anorectal cancer, Annales de Chirurgie Plastique Esthétique, 65, 4, 2020. Crossref

  16. Rengachar Poorani, Bhatt Anant Narayan, Polavarapu Sailaja, Veeramani Senthil, Krishnan Anand, Sadananda Monika, Das Undurti N., Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study, Biomolecules, 12, 6, 2022. Crossref

  17. Holzer-Geissler Judith C. J., Schwingenschuh Simon, Zacharias Martin, Einsiedler Johanna, Kainz Sonja, Reisenegger Peter, Holecek Christian, Hofmann Elisabeth, Wolff-Winiski Barbara, Fahrngruber Hermann, Birngruber Thomas, Kamolz Lars-Peter, Kotzbeck Petra, The Impact of Prolonged Inflammation on Wound Healing, Biomedicines, 10, 4, 2022. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain