图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2016015467
pages 171-183

Reversal of Lead-Induced Acute Toxicity by Lipoic Acid with Nutritional Supplements in Male Wistar Rats

Sangeeta Shukla
School of Studies in Zoology, Jiwaji University, Gwalior 474011, India
Yamini Sharma
School of Studies in Zoology, Jiwaji University, Gwalior 474011, India
Sadhana Shrivastava
Reproductive Biology and Toxicology Labora¬tory, UNESCO Satellite Center of Trace Element Research, School of Studies in Zoology, Jiwaji University, Gwalior 474011, India

ABSTRACT

Lead (Pb) is a pleiotropic toxicant. The potential role of oxidative stress injury that is associated with Pb poisoning suggests that antioxidants may enhance the efficacy of treatment designed to mitigate Pb-induced toxicity. The aim of this study is to investigate the comparative ameliorative potential of lipoic acid (LA) alone or in combination with calcium (Ca) and zinc (Zn). Pb acetate (50 mg/kg, intraperitoneally) was administered for 3 d. After 24 h of the last toxicant dose, LA (100 mg/kg, orally [po]) alone or in conjuction with Ca (50 mg/kg, po) and Zn (10 mg/kg, po) was administered for 3 d. Significant alterations in the concentration of urea, uric acid, triglycerides, cholesterol, aspartate amino transferase, alanine amino transferase, lipid peroxidation, and reduced glutathione as well as alterations in enzyme activity of δ-aminolevulinic acid (ALA) dehydratase were observed following acute Pb exposure. These findings were also supported by elevated mean DNA damage and Pb body burden in blood and soft tissues compared to controls (p ≤ 0.05). Three d posttreatment with LA along with Zn and Ca could significantly restore the biochemical parameters and Pb body burden to near-normal status through antioxidant activity or by preventing bioaccumulation of Pb within the blood and tissues of experimental rats.


Articles with similar content:

Reversal of Lead-Induced Toxicity Due to the Effect of Antioxidants
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 2
Sadhana Shrivastava, Samta Sharma, Sangeeta Shukla
Toxic Effects of Lead Exposure in Rats: Involvement of Oxidative Stress, Genotoxic Effect, and the Beneficial Role of N-Acetylcysteine Supplemented with Selenium
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Samta Sharma, Bhanu Pratap Singh Raghuvanshi, Sangeeta Shukla
Medicinal Mushroom Cracked-Cap Polypore, Phellinus rimosus (Higher Basidiomycetes) Attenuates Acute Ethanol-Induced Lipid Peroxidation in Mice
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 11
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan
Acute Exposure of Uranyl Nitrate Causes Lipid Peroxidation and Histopathological Damage in Brain and Bone of Wistar Rat
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 4
Amit Kumar, Kaushala Prasad Mishra, Badri Narain Pandey, Somnath Ghosh
Jaggery Protects Hepatorenal Injury Induced by Acute Exposure to Carbon Tetrachloride in Wistar rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 1
Vinay Sharma, Monika Sharma, Chandra Kant Sharma