图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2016013981
pages 99-107

Nephroprotective Effect of Bauhinia tomentosa Linn against Cisplatin-Induced Renal Damage

Narayanan Kannan
Department of Biotechnology, Karunya University, Karunya Nagar, Coimbatore 641 114, Tamil Nadu, India
Kunnathur Murugesan Sakthivel
Karunya University, Department of Biotechnology, Karunya Nagar, Coimbatore−641114, Tamil Nadu, India; Laboratory of Cytogenetics and Molecular Diagnostics, Regional Cancer Centre, Medical College Post, Trivandrum 695011, Kerala, India
Chandrasekaran Guruvayoorappan
Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram - 695011, Kerala, India

ABSTRACT

Cisplatin (CP) is an important chemotherapeutic drug used for the treatment of a wide variety of solid tumors. However, clinical use of CP has been limited due to its adverse effect of nephrotoxicity. In the present study, we evaluate the nephroprotective effect of Bauhinia tomentosa against CP-induced renal damage in rats. Administration of methonolic extract of B. tomentosa (250 mg/kg b.w.) results in a significant increase in antioxidant enzymes including superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). Furthermore, treatment with B. tomentosa increased body weight and relative organ weight when compared with that of the CP-induced control group. Moreover, treatment with B. tomentosa extract significantly decreased lipid peroxidation(LPO), serum urea, and creatinine when compared with the CP-induced control group. Thus, the present study highlights the potential role of B. tomentosa and its use as a new protective strategy against CP-induced nephrotoxicity


Articles with similar content:

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Prevents Doxorubicin-Induced Cardiotoxicity in Rats
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 8
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Ravindran Kalathil Veena
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Post Treatment Effect of Grewia asiatica against Radiation-Induced Biochemical Alterations in Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 2
Smita Singh, K. V. Sharma, Muktika Ahaskar, Rashmi Sisodia
Amelioration of Doxorubicin-Induced Cardiac and Renal Toxicity by Oxycarotenoid Lutein and Its Mechanism of Action
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 3
Thattaruparambil Raveendran Nithya, Ramadasan Kuttan, Edakkadath Raghavan Sindhu , Ponnamparambil Purushothaman Binitha
Protective Role of Naringenin Against Doxorubicin-Induced Cardiotoxicity in a Rat Model: Histopathology and mRNA Expression Profile Studies
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 4
Kumaresan Ganesan, Murugesan Ramachandran, Swathika Subburaman