每年出版 12 期
ISSN 打印: 0040-2508
ISSN 在线: 1943-6009
Indexed in
APPLICATION OF DIFFERENTIAL EHF DIELECTROMETRY IN MOLECULAR BIOPHYSICS
摘要
The review of the results obtained in the department of biophysics of A. Usikov Institute for Radiophysics and Electronics of NAS of Ukraine by means of an original differential dielectrometer to solve molecular biophysics problems is represented. The main attention is given to demonstration of possibilities of the method for studying of dielectric parameters, which characterize interaction of biomolecules of different levels of complexity with the aqueous solvent, in the millimeter wave band. The results of the corresponding measurements for a large set of monomeric and polymeric nucleic acids of different types as well as for proteins are given. The differential dielectrometer has been shown to be the most effective for studying small changes in the biomolecule-solvent interaction when these changes are caused by action of external factors (heating, ionizing radiation, formation of complexes with active substances, etc.). The absorption of microwave radiation by biomolecules has been found to be very low. It can not determine a biological effect of this radiation. In biomolecule solutions the main component, which interacts with microwaves, is water in the Debye dispersion range.
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Shestopalova Anna Victorovna, Pesina Daryna A., Kashpur Vsevolod A., Khorunzhaya Olga V., Hydration of DNA-binding biological active compounds: EHF dielectrometry and molecular modeling results, Structural Chemistry, 27, 1, 2016. Crossref
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Kashpur V. A., Khorunzhaya O. V., Pesina D. A., Shestopalova A. V., Maleev V. Ya., Hydration effects accompanying the formation of DNA complexes with some ligands, Biophysics, 62, 1, 2017. Crossref